Dr. Fouladi is the Head of the research team Jaxen's Journey is funding at Cincinnati Children's. She was nice enough to give us an update on what the donations are being used towards. Thank you for the update Dr. Fouladi!
We propose to assess the genomic landscape of children and adults with
pineoblastoma and primitive neuroectodermal tumors in general to build on data that
have recently been published (Snuderl et al, 2018, Hwang et al, 2018) to demonstrate
the unique biological characteristics of these tumors that may help us to improve our
treatments and lead to better outcome and survival for young children with these
With the funds that we have received, we propose to do the following:
1. Conduct whole genome, whole exome, RNA sequencing and methylation
profiling of available tumors here at CCHMC and our collaborators at others
centers to build on our growing knowledge and understanding of these tumors
2. To develop an international feasibility study with novel agents and approaches
for children with pineoblastomas and embryonal tumors in general through the
CONNECT Consortium, a 19-member international consortium with sites in the
US, Canada, Australia, England, Germany and the Netherlands.
The ultimate goal is to develop better therapies to improve the outcome of children with
pineoblastoma, and embryonal tumors around the world.