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Note From Dr. Fouladi

Dr. Fouladi is the Head of the research team Jaxen's Journey is funding at Cincinnati Children's. She was nice enough to give us an update on what the donations are being used towards. Thank you for the update Dr. Fouladi!

Pineoblastoma Research

We propose to assess the genomic landscape of children and adults with

pineoblastoma and primitive neuroectodermal tumors in general to build on data that

have recently been published (Snuderl et al, 2018, Hwang et al, 2018) to demonstrate

the unique biological characteristics of these tumors that may help us to improve our

treatments and lead to better outcome and survival for young children with these


With the funds that we have received, we propose to do the following:

1. Conduct whole genome, whole exome, RNA sequencing and methylation

profiling of available tumors here at CCHMC and our collaborators at others

centers to build on our growing knowledge and understanding of these tumors

2. To develop an international feasibility study with novel agents and approaches

for children with pineoblastomas and embryonal tumors in general through the

CONNECT Consortium, a 19-member international consortium with sites in the

US, Canada, Australia, England, Germany and the Netherlands.

The ultimate goal is to develop better therapies to improve the outcome of children with

pineoblastoma, and embryonal tumors around the world.

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